anavar cycle for women

Improves brain metabolism, increasing glucose and oxygen consumption of brain tissue. Increases resistance of neurons to hypoxia; enhancing glucose transport to the brain through the blood-brain barrier; It translates the process of disintegration of glucose to energy more economical, aerobic pathway; selectively blocks calcium-dependent phosphodiesterase; increases the levels anavar cycle for women of adenosine monophosphate  and cyclic guanosine monophosphate exchange enhances brain noradrenaline and serotonin; stimulates the ascending branch of the noradrenergic system, has an antioxidant effect. Reduces the aggregation of platelets and increased blood viscosity; increases the deforming ability of red blood cells and red blood cells block the recycling of adenosine; enhances oxygen release by red blood cells. It enhances the neuroprotective action of anavar cycle for women adenosine. Increases cerebral blood flow; reduces the resistance of cerebral vessels without significant changes in the systemic circulation parameters (blood pressure, minute volume, heart rate, total peripheral resistance). Not only does not have “steal” effect, and increases blood flow, especially in ischemic brain regions with low perfusion.  rapidly absorbed, at 1 h after oral administration to reach the maximum blood concentration. Absorption takes place mainly in the proximal gastrointestinal tract. When passing through the intestinal wall is not metabolized.

 

CONTRAINDICATIONS
Acute phase of a hemorrhagic stroke, a severe form of coronary heart disease, severe arrhythmia and known hypersensitivity to vinpocetine and lactose intolerance. Pregnancy and lactation: Pregnancy, because vinpocetine crosses the placental barrier. Thus its concentration in the placenta and fetal blood is lower than in the blood of pregnant. At high doses may placental bleeding and spontaneous abortion, probably due to increased placental blood supply. Lactation: for an hour in the breast milk gets 0.25% of the dose of the drug. In applying the drug must stop breastfeeding. Children younger than 18 years (due to lack of data)

DOSAGE AND ADMINISTRATION
The course of treatment and dosage is determined by the attending physician.
Inside, after a meal.
Usually a daily dosage of 15-30 mg (5-10 mg 3 times a day).
The initial daily dose is 15 mg. The maximum daily dose of 30 mg. The therapeutic effect is about a week from the beginning of treatment. Course of treatment 1-3 months.
In the kidney and liver drug administered in the usual dose, absence of cumulation allows for long-term treatments.

SIDE EFFECTS
Side effects during treatment with the drug is rarely detected. Since the cardiovascular system: ECG changes (depression ST, prolongation of QT interval); tachycardia, arrythmia, however, a causal anavar cycle for women relationship has not been proved since in natural populations of these symptoms occur with the same frequency; labile blood pressure, feeling the tides. On the part of the central nervous system: sleep disorders (insomnia, excessive sleepiness), dizziness, headache, fatigue (these symptoms may be manifestations of the underlying disease), increased sweating. On the part of the digestive system: dry mouth, nausea, heartburn. Allergic skin reactions.

Overdose
At present, data on overdose vinpocetine limited.
Treatment of overdose: gastric lavage, activated charcoal, symptomatic therapy.

Vzamodeystviya DRUG
interaction was observed while the use of beta-blockers (hloranolol, pindolol) Klopamid, glibenclamide, digoxin, acenocoumarol and hydrochlorothiazide, imipramine
Concomitant use Cavinton ® and methyldopa sometimes caused some increase in the hypotensive effect, so if such treatment is required regular blood pressure control.
Despite the lack of evidence supporting the possibility of interaction, it is recommended to be cautious while appointing a central drugs, antiarrhythmic and anticoagulation action.

SPECIAL INSTRUCTIONS
The presence of prolonged QT interval syndrome and receiving drugs that cause lengthening of the QT interval, requires periodic ECG monitoring.
Tablets Cavintonum ® contains lactose. In case of intolerance to lactose should note that one tablet anavar uk contains 41.50 mg of lactose monohydrate.

The action of the drug on the ability to drive: data on the effect of Vinpocetine on the ability to drive a car and anavar cycle for women working mechanisms, not.

Composition
Tablets of 5 mg.
Of 25 tablets in a blister made ??of PVC / Al. 2 blisters in a cardboard box with instructions for use

Shelf life
5 years.
Do not use beyond the expiration date printed on the package.

Storage conditions
List B.
At a temperature of 15-30 ° C, in a dark place, out of reach of children.

Conditions of supply of pharmacies
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Alprostadil, naturally occurring form of prostaglandin E 1 has a broad spectrum of pharmacological action. Among the most significant of its effects should be noted vasodilation and inhibition of platelet aggregation.
If intracavernous introduction anavar pills alprostadil inhibits α1-adrenergic receptors in tissues, relaxes the muscles of the corpora cavernosa, increases blood flow and improves microcirculation. Alprostadil causes an erection by relaxation of trabecular smooth muscle and dilation of the corpus cavernosum of the cavernous arteries, which leads to expansion of lacunar spaces and occlusion by pressing the venules to the protein shell .

For the treatment of erectile dysfunction, alprostadil is injected in the cavernous body of the penis. The absolute bioavailability of alprostadil is not defined. Distribution: Following intracavernosal injection of 20 micrograms alprostadil average peripheral plasma concentration after 30 and 60 min after injection . No significant anavar pills binding to erythrocytes or leukocytes were observed. Metabolism: Alprostadil is rapidly converted to compounds that, in turn, is metabolized before excretion. About 80% of circulating alprostadil is metabolized during the first passage through the lungs, primarily by beta- and omega-oxidation. Primary metabolites alprostadil. After intracavernosal administration of 20 .mu.g of alprostadil main circulating metabolite content of 13,14-dihydro-15-oxo-PGE- 1 in peripheral blood flow is increased and reaches a maximum after 30 minutes and then returned to the original level after 60 minutes after the administration, while the levels of alprostadil in the peripheral circulation remains slightly above the original.  Possible effects of age or race on the pharmacokinetics of alprostadil following intracavernosal administration has not been assessed. The duration of the carcinogenicity studies of alprostadil has not been. There were no mutagenic potential of alprostadil. Alprostadil at a dose of 2 mg / kg / day, administered subcutaneously, it does not affect reproductive function and does not cause changes in spermatogenesis.

The interaction with other drugs
Kaverdzhekt not for mixing or concomitant administration with other drugs, as well as for use with other drugs for the treatment of erectile dysfunction. The possibility of pharmacokinetic interactions with other drugs have not been studied. The combined use of antihypertensive drugs, diuretics, antidiabetic agents (including insulin), or nonsteroidal anti-inflammatory drugs do not exert any influence anavar pills on the safety or efficacy of the drug Kaverdzhekt. The safety and efficacy of the joint use of the drug Kaverdzhekt other vasoactive drugs has not been studied.
The presence of benzyl alcohol in the solvent reduces the degree of binding to the bottle walls. In this regard, when using water for injection comprising benzyl alcohol, a stable solution is obtained and ensures a more complete administration of the drug.

special instructions

  1. Before the start of drug therapy should be carried out Kaverdzhekt diagnosis treatable causes of erectile dysfunction.
  2. The first injection of the drug must be performed in the doctor’s office by specially trained medical personnel. Self-injection can be started only after a detailed briefing of the patient and the development of their self-injection technique. The physician should carefully evaluate the skills of the patient and its ability to conduct the procedure. Intracavernosal administration should be performed under aseptic conditions.
  3. It is necessary to carry out continuous monitoring anavar pills of the patient, conducting self-treatment, particularly during the initial period when you may need to change the dose. Every 3 months the patient should visit the doctor to assess the efficacy and safety of treatment and dose adjustment (if necessary).
  4. Bottle dilute the drug is intended for single use and discarded after use. the patient should be instructed about the rules of the needle destruction, syringe and vial.
  5. It is known that after intracavernosal administration of vasoactive drugs, including Kaverdzhekt can develop priapism (an erection lasting more than 6 hours). To reduce the risk of priapism be administered lowest effective dose. The patient should immediately tell your doctor about all the cases, an erection lasting more than 4 hours. priapism treatment is carried out in accordance with established medical practice.
  6. After intracavernosal administration of the drug can develop penile fibrosis, including angulation of the penis, the formation of fibrotic nodules and Peyronie’s disease. The incidence of fibrosis may increase with increasing duration of use of the drug. In order to detect signs of penile fibrosis or Peyronie’s disease is strongly anavar pills recommended that regular screening of patients with careful examination of the penis. In patients with the development of penile angulation, cavernous fibrosis or Peyronie’s disease treatment with the drug should be discontinued.
  7. Since the intracavernous administration may slight bleeding, patients applying Kaverdzhekt should be aware of the measures to protect against infections, sexually transmitted infections, as well as through the blood, including human immunodeficiency virus (HIV). Patients receiving treatment with anticoagulants such as warfarin or heparin, have an increased propensity for bleeding after the intracavernous injection.
  8. Special monitoring is necessary in patients receiving MAO inhibitors, and in the case of prolonged erection in the treated α-agonists (may develop a hypertensive crisis); as well as in patients with coronary artery disease, congestive heart failure or pulmonary disease (sexual stimulation and sexual intercourse can lead to an exacerbation of the disease).
  9. It is necessary to strictly observe the compliance with the dosage form alprostadil specific indications for its use.

 

Release form
Valium for solution for intracavernosal injection of 10, 20 mg (bottles) / together with the solvent – water for injections with benzyl alcohol 9 mg / ml disposable syringe) 1 ml of the needle for injection – 2 pcs.and napkins – 2 pieces with instructions for use in a plastic box.

Shelf life
Shelf life of the lyophilisate: 2 years.
Shelf life of the solvent:. 3 years
Do not use after the expiry date!

Storage conditions
List B. The temperature is not above 25 ° C. Do not freeze! The diluted solution stored in the original vial at no vyshё 25 ° C for up to 24 hours. Do not freeze or refrigerate! Keep out of the reach of children! legal steroids

anavar cycle

Anticancer agent containing the heavy metal platinum. Cisplatin has properties similar to those of the bifunctional alkylating agents, and vnutrityazhevye mezhtyazhevye forming crosslinks in the DNA thereby destroying its function, leading to cell anavar cycle death; wherein the drug has no cyclic phase and specificity. It possesses immunosuppressive and radiosensitizing properties.  After rapid intravenous infusion (15 min – 1 hour) in the emergence of cisplatin and the peak plasma concentration is determined immediately after administration. Intravenous infusions for 6-24 hours in plasma drug concentration increases gradually during infusion, reaching a maximum at the end of administration. Cisplatin is characterized by extensive distribution in the body fluids and tissues; with the highest concentrations are achieved in the kidney, liver and prostate. Cisplatin biotransformation is performed by rapid non-enzymatic reaction with the formation of inactive metabolites. Cytotoxic effect has only cisplatin is not associated with proteins, or a platinum-containing metabolites. After blasting, injection or intravenous infusion duration from 2 to 7 hours in a dosage range of from 50 to 100 mg / m² half-life of cisplatin from plasma is approximately 30 minutes. After administration of 100 mg / m, and the ratio between the total free cisplatin (ultrafiltered) platinum in plasma ranges from 0.5 to 1.1. Three hours after the bolus administration, and two hours after anavar cycle a three-hour infusion of 90% of the total free platinum is protein-bound in plasma state. With repeated courses of therapy occurs platinum accumulation in body tissues, and platinum is found in some tissues for a further six months after the last dose of drug. Half-life of total platinum is very wide individual variability and ranges from 2-72 hours in healthy people, and 1-240 hours in advanced renal failure. After 1 hour after administration of cisplatin, most of the drug is excreted through the kidneys in unchanged form. The renal clearance of free (ultrafilter) platinum also exceeds creatinine clearance, is nonlinear and depends on the dose, urine flow rate and the individual characteristics of tubular secretion and reabsorption of the patient. A strict correlation between renal clearance of free (ultrafilter) plugins or cisplatin and creatinine clearance is not established. With daily administration of the drug there is a risk of accumulation of free (ultrafilter) platinum in plasma. For other modes of administration no such risk. After dosing low concentrations of platinum found in the bile and the large intestine, but platinum excretion path through the digestive tract is small. Cisplatin may be derived from anavar cycle the systemic circulation by dialysis, but only during the first 3 hours after drug administration.

  • Germ cell tumors of women and men
  • Ovarian cancer and testicular
  • Small cell and non-small cell lung cancer
  • Squamous cell carcinoma of the head and neck
  • Bladder cancer
    Furthermore, cisplatin has antitumor activity for the following types of tumors:
  • Cervical cancer
  • osteosarcoma
  • Melanoma
  • sympathicoblastoma
  • Esophageal carcinoma

    Contraindications

  • Hypersensitivity of cisplatin or other compounds containing platinum;
  • Impaired renal function (serum creatinine over 115 mmol / titer);
  • Inhibition of bone marrow hematopoiesis;
  • Pregnancy and lactation.Be wary – hearing loss, polyneuritis, acute infectious diseases, chicken pox (including recently transferred or recent contact with sick), shingles, gout is a history of nephrolithiasis, radiation or chemotherapy history.

    Dosing and Administration

    Kemoplat can be used both as monotherapy and in combination with other cytostatic at different doses depending on the regimen. At individual dose selection should be guided by the data of literature.
    Kemoplat intravenously or testimony (intraperitoneal tumors) to the abdominal cavity.
    Kemoplat in monotherapy and in combination anavar cycle with other chemotherapy is usually administered in a dose of 50-100 mg / m² as an intravenous infusion every 3 4 weeks, or 15-20 mg / m² intravenously daily for 5 days every 3-4 weeks.

    Guidelines for the preparation and administration of the solution for intravenous infusion
    In order to stimulate urine output (up to 100 mL / hr) and to minimize the nephrotoxicity of the drug carried hydration. Prior to administration of cisplatin intravenously administered up to 2 liters of fluid.Excessive fluid intake and maintain a diuresis must be observed for 24 hours. If intense hydration to maintain adequate urine output is insufficient, you can enter an osmotic diuretic (eg, mannitol).
    Cisplatin is administered intravenously at a rate of no more than 1 mg / min. Long-term infusion held within 08/06/24 hours provided adequate diuresis before administration and during administration.
    Cisplatin is diluted in one of these infusion solutions: 0.9% sodium chloride solution; 0.9%, 0.45% or 0.3% sodium chloride solution in 5% glucose solution. Diluted solutions of the drug stable for 6-8 hours at a temperature no higher than 25 ° C in a dark place.
    Note: Since the aluminum reacts with cisplatin and inactivates it. and also causes the formation of sludge, is important in anavar cycle the preparation and administration of cisplatin does not use needles and other material containing aluminum.

    Side effect

    From the urinary system: Renal toxicity is cumulative and is a major toxic factor limiting the dose of cisplatin. Defeats of kidneys, which are accompanied by damage to the renal tubules can be identified for the first time in the second week after a dose and is manifested by increased serum creatinine, urea, uric acid in the serum and / or a decrease in creatinine clearance. Renal toxicity, as a rule, is low to moderate and is reversible at the usual doses of cisplatin. From the electrolyte balance: hypomagnesemia, hypocalcemia, hyponatremia, hypokalemia and hypophosphatemia. Hypomagnesemia and / or hypocalcemia may manifest clinically enhanced muscle sensitivity or seizures, tremor, karpopedalnym spasm (cramps in the hands and feet) and / or tetany. Hyponatremia is usually caused by the syndrome of inappropriate antidiuretic hormone production. On the part of the gastrointestinal tract. Nausea and vomiting, which usually begin during the first hour of therapy and continued for 24 hours or more, are found in almost all patients. These side effects are partially eliminated by the use of standard antiemetics. Severity of these symptoms can be reduced by dividing the total dose, calculated on the treatment cycle into smaller doses which are administered once a day for five days. Among other frequently observed adverse events from the gastrointestinal tract marked by abdominal pain, diarrhea and constipation. From the hematopoietic system. The therapy with cisplatin often develop myelosuppression, but in most cases it is expressed mild or moderate, and when applying the usual dosage It is reversible. The lowest levels of white blood cells and platelets are generally observed with the 18 th to 23 th day after administration; the majority of patients, these figures restored to the 39th day. Also, there may be anemia. On the part of the hearing system. Unilateral or bilateral tinnitus, hearing loss or no loss occurs in about 10% of patients treated with cisplatin, typically this side effect is reversible. It was established that the organ of hearing loss is dose-dependent and cumulative, and this side effect more frequently observed in patients are very young or elderly. There are reports of toxic effects of the drug on the vestibular apparatus. From the central and peripheral nervous system. Peripheral neuropathies occur infrequently. Usually they have a sensory nature (eg, paresthesias of the upper and lower limbs), but may also occur, motor disorders (decreased reflexes, and weakness in the lower limbs). Also they can be marked autonomic neuropathy, convulsions, slurred speech, loss of taste and memory loss. It reported on the development of a symptom Lhermitte, myelopathy of the spinal column, and autonomic neuropathy. Drug treatment should be discontinued at the first appearance of symptoms.Hypersensitivity. Sometimes there allergic reactions manifesting as redness and swelling of the face, wheezing in the lungs, tachycardia and hypotension. These reactions may occur within a few minutes after the administration of cisplatin. In rare cases, there may be urticaria, and maculopapular rash. On the part of the system. In rare cases, there are optic neuritis, nipple swelling of the optic nerve, cortical blindness. Also, there may be color perception change, particularly in the yellow-blue part of the spectrum. The only change in the fundus of the eye may be irregular pigmentation of the retina in the macula.These side effects are usually reversible and disappear after discontinuation of the drug. The toxic effect on the liver. Occasionally may experience minor and transient increase in ACT levels of ALT and serum bilirubin. Other side effects. Violations of the cardiovascular system (coronary heart disease , myocardial infarction, stroke, congestive heart failure, arrhythmia, orthostatic hypotension, thrombotic microangiopathy, cerebral arteritis), hyperuricemia, increased levels of serum amylase, slight alopecia, myalgia, fever, hiccups and gingival platinum line. If the product enters the skin may develop phlebitis, inflammation of the subcutaneous fat and skin necrosis. Cases of violation of spermatogenesis and azoospermia.

    Interaction with other medicinal products and other forms of interaction

    The simultaneous or sequential application of cisplatin, aminoglycoside antibiotics (gentamicin, kanamycin, streptomycin) or with other potentially nephrotoxic drugs (eg, amphotericin B) may potentiate its nephrotoxic and ototoxic effects.
    “Loop” diuretics (furosemide, clopamide, ethacrynic acid) may strengthen ototoxicity of cisplatin.
    it is known that cisplatin may interfere with the excretion through the kidneys bleomycin and methotrexate (possibly due to cisplatin-induced nephrotoxicity) and enhance the toxicity of these drugs.
    In an application of cisplatin, hexamethylmelamine and pyridoxine in the treatment of ovarian cancer was a decrease in the duration of remission.
    patients receiving cisplatin and anticonvulsants last concentration in serum may be reduced up to values ??subtherapeutic.
    cisplatin may cause an increased concentration of uric acid in the blood. Therefore, patients who take both drugs for the treatment of gout such as allopurinol, colchicine, probenecid or sulfinpyrazone, correction may be necessary dosage of these drugs, to control attacks of gout and hyperuricemia.
    The reaction of cisplatin with aluminum precipitate formed.

    Overdose

    The main expected overdose complications are renal dysfunction, liver, visual disturbances (including retinal detachment) and hearing loss (deafness), severe myelosuppression, nausea and uncontrollable vomiting and / or neuritis. In case of overdose may be fatal.
    The antidote in case of an overdose of the drug is unknown Kemoplat. The effect, at least partially, is achieved only by dialysis, if it is used for the first three hours of the overdose, as platinum rapidly bound to plasma proteins. To eliminate the symptoms of overdose symptomatic treatment applied.

    special instructions

     

    • The drug should be used under the supervision of a physician who is experienced in the use of anticancer drugs.
    • Women of childbearing age is recommended during treatment with cisplatin to use contraceptives.
    • Men receiving cisplatin therapy should use barrier methods of contraception.
    • Patients on treatment with cisplatin should be inspected periodically neurologist. When obvious symptoms of toxic effects on the CNS cisplatin therapy should be discontinued.
    • Before starting therapy should be audiometry, and in cases where there are symptoms of the organ of hearing or hearing impairment are detected clinically, shows repeated audiometry. If clinically significant hearing impairment may require a dosage adjustment or cancellation of therapy.
    • In the treatment of cisplatin requires periodic analysis of blood, determination of the content of leukocytes, platelets, hemoglobin, blood counts, liver and renal function tests, electrolytes and blood serum.Re drug should not be administered for as long as the content of serum creatinine is reduced to 1.5 mg / 100 ml or less and / or blood urea nitrogen is reduced to 25 mg / 100 ml or less of blood platelet content is 100 000 / mm³, leukocytes – not less than 4000 / mm³.
    • With the development of allergic reactions in the form of facial edema, bronchospasm, tachycardia and hypotension should use epinephrine, corticosteroids and drugs antigisgaminnye.
    • When using Cisplatin must be observed all the usual regulations adopted for the application of cytotoxic drugs.
    • In case of contact with the drug in their eyes, rinse immediately with plenty of water or sodium chloride solution. In case of contact with the drug on the skin, rinse immediately with a place of contact with plenty of water. In case of inhalation of the drug or getting it in your mouth you should immediately consult a doctor.

    release Form

    Concentrate for solution for infusion at 20 ml / 100 ml and 10mg / 50mg in orange glass bottles. 1 bottle in a cardboard box with the accompanying instructions for use.

    Storage conditions

    List A. Store at 15 ° – 25 ° C, protected from light and out of reach of children.

    Shelf life

    2 years.
    Do not use the drug after the expiry date stated on the package.

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anavar dosage

Has a local anavar dosage anti-inflammatory and antiseptic action.
minor skin damage , superficial burns , biting insects .Hypersensitivity to the drug, festering wounds, nonhealing wounds.Outwardly. In the treatment of superficial burns ointment applied thinly to the affected areas of the skin, under sterile bandage 2-3 times a day for 1-3 weeks. In the treatment of minor wounds, abrasions, insect bites anavar dosage ointment applied thinly to the damaged areas of the skin 2-3 times a day.

Side effects:
Allergic reactions are possible. In rare cases – the emergence of dermatitis at the site of application.

Form release
ointment for external use. 25 g amber glass jar with a lid or tensioned to 25 g and 40 g of a glass jar with a lid unified-screw-type closure. 25 g of aluminum into a tube made ??of polyethylene with a bud. Every jar and tube together with instructions for use placed in a pile of cardboard boxed.

For hospitals, banks of 100 pieces (packing 25g) or 60 pieces (packing 40 g), together with an equal number anavar dosage of instructions for use are placed in boxes or cardboard boxes.

Storage:
In a cool and out of reach of children.

Shelf Life
1 year and 6 months. Do not use after anavar dosage the date printed on the package.

Conditions of supply of pharmacies.
No prescription.

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Combined medication. Lidocaine hydrochloride – has a local anesthetic effect, which is caused by anavar results inhibition of nerve conduction by blocking sodium channels.Cetylpyridinium chloride • ANTISEPTIC means the vast growth of some bacteria and fungi.
Pain teething in children from 5 months of age. Hypersensitivity to lidocaine, cetylpyridinium, or any other component of the formulation. Renal or hepatic impairment, hypotension, cardiac insufficiency II-III degree, violation of intraventricular conduction, bradycardia.

Dosing and Administration
Locally. Before applying Kalgel anavar results should consult with a pediatrician. A small amount of gel (about 7.5 mm) is applied to the tip of a clean finger and gently rubbed into the gums sore child site. If necessary, the gel can be applied repeatedly at intervals of not less than 20 minutes but not more than 6 times per day.

Side effects:
Allergic reactions (urticaria, pruritus, anaphylactic shock). Possible violation of swallowing.
If, during the application of the gel shows signs of an allergy, then the drug should be discontinued and seek medical advice.

Overdose
Symptoms: vomiting, anavar results  pallor, bradycardia, respiratory center depression, apnea. In case of overdose should be abolished Kalgel and seek medical advice.

Interaction with other drugs
in the event of the need for other medications, consult your doctor.

Cautions
Do not exceed the recommended dose, because it is necessary to take into account the possibility of anavar results swallowing the drug in the feeding and at bedtime.

Product form
10 g in aluminum tube, coated on the inside with lacquer, plastic with screw cap.
1 tube together with instructions for use in paper cartons.

Shelf life
3 years.
Do not use after the expiration date.

Storage conditions:
The temperature is not above 25 ° C.
Keep out of reach of children.

Conditions of supply of pharmacies
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