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Orotic acid is a precursor of pyrimidine nucleotides making up the nucleic acids, which are involved in the synthesis of protein molecules, and therefore, orotic acid salt are considered as buy anavar a substance anabolic and applied in disorders of protein metabolism, for their stimulation.
Typically the potassium salt is used orotic acid (orotate potassium). Potassium orotate stimulates the synthesis of nucleic acids, albumin production in the liver (especially in conditions of prolonged hypoxia) increases appetite, a diuretic, regenerative properties.
Following oral administration in the gastrointestinal tract is absorbed 10% of an oral dose. The liver is converted into orotidine-5-phosphate. Excreted in the urine (30% as a metabolite). Indications for use
as an aid in the treatment of liver and biliary buy anavar tract (caused by acute and chronic intoxication, with the exception of organic liver disease and biliary tract):
– as part of combination therapy for chronic heart failure and heart rhythm disturbances;
– alimentary and alimentary infectious malnutrition in children
– chronic physical stress.

 

Dosage and administration
should be taken orally 1 hour before meals or after 4 hours after eating. Adults: 250-500 mg 2-3 times a day. The course of treatment lasts on average 20-30 days. If necessary, the treatment can be repeated after one month. In exceptional cases, can increase the adult dose to 3 g per day. Babies – 10-20 mg / kg body weight per day, divided into 3-4 doses (for example, if the child’s body weight is 25 kg buy anavar the permissible dose – 25 x 10 = 250 mg (Table 1.2) to 25. x 20 = 500 mg (1 tab. per day, divided into 3-4 receptions). The course of treatment 3-5 weeks.
If symptoms persist, consult a doctor illness.

Side effects
usually Potassium Orotate well tolerated. In some cases there may be allergic skin reactions that disappear after treatment interruption. Potassium orotate can also cause mild digestive disorders (nausea, vomiting). When used in high doses on a buy anavar background of low-protein diet may develop liver disease.
When side effects, consult a physician.

Overdose
Data on overdose are not available.

Interaction with other drugs
Potassium Orotate slightly reduces the toxicity of cardiac glycosides; improved effect when combined with magnesium preparations. Cementing and enveloping means may somewhat reduce the absorption of potassium orotate in the gastrointestinal tract.

Cautions
Do not cause drowsiness and decrease the speed of psychomotor reactions. During treatment, it is desirable to dieting.

Form release
Tablets 500 mg.
10 tablets in contour bezgyachakova packaging made ??of paper coated or film material combined tseflena.
10 tablets in blisters of PVC film and aluminum foil printed patent. 10 tablets in blisters of PVC film and aluminum foil printing lacquered and flexible packaging in rolls on the basis buy anavar of aluminum foil for drugs.
In 10 or 20 tablets in a jar or bottle polymer resin. Each jar or bottle, or 1, 2 or 3 blisters with instruction on use are placed in a pile of cardboard. 100, 150 bezgyachakova contour packs or 100, 150 along the contour of cellular packages with the same number of instructions for use placed in bags of polyethylene film.

Storage conditions
In a dry place, protected from light and the reach of children at or above 25 C.

Shelf life
4 years. After the expiry date stated buy anavar on the package, do not use. azab 250 jay cutler bodybuilder 2013 lipolaser machine for sale bodybuilding living large

liquid anavar

Preparation which contains in its composition lopinavir and ritonavir. Lopinavir is an inhibitor of the protease of , human liquid anavar immunodeficiency virus and provides antiviral activity of the drug. The inhibition of HIV protease prevents the synthesis of viral proteins and prevents cleavage of the polypeptide gag-pol, which leads to the formation of immature and unable to infection by the virus. Ritonavir inhibits isoenzyme  metabolism of lopinavir in the liver, leading to an increase of lopinavir plasma concentration. Ritonavir is also an inhibitor of HIV protease. Resistance isolates with reduced susceptibility to lopinavir have been selected  presence of ritonavir does not influence the selection of lopinavir-resistant viruses in  treatment in patients not previously treated with therapy were analyzed viral isolates from each patient with a  . A further increase in viral load was associated with the introduction of additional mutations associated with the development of resistance to protease inhibitors of HIV. However, these data are insufficient to identify the mutations responsible for the development liquid anavar of resistance to lopinavir. Cross-resistance of today is not enough of cross-resistance during therapy with the development of data . lopinavir / ritonavir virologic response to therapy with lopinavir .

Pharmacokinetics
The pharmacokinetics of lopinavir in combination with ritonavir was studied in healthy volunteers and HIV-infected patients; significant differences between the two groups did not reveal. Lopinavir is almost completely metabolized by the action of liquid anavar isoenzyme CYP3A. Ritonavir inhibits the metabolism of lopinavir and causes an increase in its concentration in plasma. In the application of lopinavir / ritonavir 400/100 mg dose twice daily average equilibrium lopinavir plasma concentration in HIV infected patients is 15-20 times higher than those of ritonavir and ritonavir plasma concentration was less than 7% of the concentration at reception in ritonavir 600 mg twice daily. EC 50 lopinavir in vitro is approximately 10 times lower than that of ritonavir. Thus, the antiviral activity of the combination of lopinavir and ritonavir, lopinavir is determined.
When the meal concentration of lopinavir and ritonavir in the blood plasma after taking two tablets 200/50 mg is equivalent to three capsules at 133/33 mg with minimal variability in pharmacokinetics.Absorption In a pharmacokinetic study in HIV -positive patients (n = 19), when receiving the 400/100 mg lopinavir / ritonavir twice daily together with food for three weeks, the average value of the maximum quantity of lopinavir plasma concentration (C max ) 3.7 ± 9,8 g / ml, it was noted after about four hours after taking the drug. The average equilibrium concentration before the morning dose was 7.1 ± 2.9 mg / ml and the minimum concentration within the dosing interval was 5.5 ± 2.7 pg / ml. The area under the curve “concentration-time» (AUC) for lopinavir 12 hours after taking the drug averaged 92,6 ± 36,7 mkg⋅ch / ml. The absolute bioavailability of lopinavir in combination with ritonavir in humans has not been established. Distribution In the equilibrium state of about 98 – 99% of lopinavir are in communication with the plasma proteins. Lopinavir binds to alpha 1-acid glycoprotein (ACS) and albumin, however, lopinavir higher affinity for ACS. In equilibrium binding of lopinavir plasma proteins remains constant in the range of reported concentrations, poses after receiving the 400/100 mg lopinavir / rntonavira twice a day, and is comparable in healthy volunteers and HIV-positive patients. Metabolism Studies in vitrodemonstrated that lopinavir predominantly undergoes oxidative metabolism involving liquid anavar cytochrome P450 hepatocytes, mainly under the influence of isoenzyme CYP3A. Ritonavir – a potent inhibitor of isoenzyme CYP3A, which inhibits the metabolism of lopinavir, lopinavir that provides an increase in plasma concentrations. After a single dose of 400/100 mg lopinavir / ritonavir (labeled with 14 C- lopinavir), 89% of the radioactivity provided the original drug. In humans, it has been revealed at least 13 lopinavir oxidative metabolites. Ritonavir is able to induce the cytochrome P450 isozymes, which leads to the induction of its own metabolism. During prolonged use lopinovira concentration before taking the next dose decreased over time, stabilizing after approximately 10-16 days. Withdrawal After receiving 400/100 mg 14 C-lopinavir / ritonavir eight days approximately 10,4 ± 2,3%, and 82, 6 ± 2,5% of the administered dose of 14 C-lopinavir found in the urine and feces, respectively. Moreover unmodified lopinavir is respectively 2.2 and 19.8%. After prolonged use of less than 3% of the dose of lopinavir is excreted in unchanged form via the kidneys. The clearance (CL / F) of lopinavir ingestion of 5.98 +/- 5.75 l / h. The reception once daily pharmacokinetics of lopinavir / ritonavir, with a multiplicity of receiving once daily was evaluated in HIV-infected patients not receiving prior antiretroviral therapy. Lopinavir / ritonavir 800/200 mg was used in combination with emtricitabine and tenofovir 200 mg 300 mg once a day daily. Chronic administration of 800/200 mg lopinavir / rntonavira once a day for 4 weeks during a meal the average maximum plasma concentration of lopinavir in (the C max ) was 11,8 ± 3,7 mg / ml and reaches about 6 hours after administration. Lopinavir liquid anavar average equilibrium concentration before taking the morning dose was 3.2 ± 2.1 mg / ml, the lowest concentration within the dosing interval was 1.7 ± 1.6 pg / ml. Lopinavir AUC at 24-hour reception interval averaged 154,1 ± 61,4 mkg⋅ch / ml. Special group sex, race and age of the pharmacokinetics of lopinavir has not been studied in elderly patients. No sex-dependent pharmacokinetic differences were observed in adult patients. No clinically significant pharmacokinetic differences depending on race also has been established. Children Pharmacokinetics lopinavir / ritonavir 300/75 reception mg / m 2 twice daily and 230 / 57.5 mg / m 2 twice daily were studied for a total of 53 patients aged 12 years. Driving dosing 230 / 57.5 mg / m 2 twice daily without nevirapine and the 300/75 mg / m 2 twice daily with nevirapine provided lopinavir plasma concentrations similar to those obtained in liquid anavar adult patients receiving 400/100 mg for twice a day (without nevirapine). Receiving Lopinavir / ritonavir once a day in children has not been studied. Average equilibrium AUC, C max, and C min lopinavir after administration of lopinavir / ritonavir 230 / 57.5 mg / m 2 twice daily without nevirapine (n = 12) were 72.6 ± 31,1mkg⋅ch / ml; 8.2 ± 2.9 and 3.4 ± 2.1 mcg / mL, respectively; and 85.8 ± 36.9 mkg⋅ch / ml, 10.0 ± 3.3 and 3.6 ± 3.5 mcg / ml, respectively, after receiving 300/75 mg / m 2 twice daily with nevirapine (n = 12). Scheme NVP was 7 mg / kg twice a day (in patients from six months up to eight years) or 4 mg / kg twice a day (in patients older than eight years). Renal insufficiency Pharmacokinetics lopinavir has not been studied in patients with renal failure; however, since the renal clearance of lopinavir is negligible, lower total clearance in patients with renal insufficiency is not expected. Liver failure Lopinavir predominantly metabolized and excreted by the liver. The combined dosing of lopinavir / ritonavir at 400/100 mg twice daily in patients co-infected with HIV and hepatitis C, liver failure resulting in moderate 30% increase in AUC of lopinavir and 20% increase in the C max as compared to the HIV-infected patients with normal liver function. Lopinavir liquid anavar plasma protein binding was lower when compared to the control groups mild to moderate hepatic impairment (99.09 compared with 99.31%, respectively). Lopinavir / ritonavir has not been studied in patients with hepatic impairment, severe (see “Contraindications” section.). Drug Interactions (See also:. “Contra,” “Precautions,” “Special instructions”, “Interactions with other drugs “). Lopinavir / ritonavir in vitro inhibits the isoenzyme of CYP3A. The simultaneous use of lopinavir / rntonavira and drugs metabolized isoenzyme CYP3A, may lead to increased concentrations of the drug in the plasma, which can enhance or prolong the therapeutic or side effect (cm. “Contraindications”). Lopinavir / ritonavir does not inhibit isoenzymes CYP2D6, CYP2C9, CYP2C19, CYP2E1, CYP2B6 or CYP1A2 at therapeutic concentrations. Lopinavir / ritonavir in vivo to induce its own metabolism and enhances the biotransformation of some drugs metabolized by cytochrome P450 and glyukuronirovaniya. Lopnnavir / ritonavir is metabolized with the participation of isoenzyme of CYP3A. It is expected that agents that induce isoenzyme CYP3A, lopinavir clearance may increase, which may lead to a decrease in plasma concentrations of lopinavir. Concomitant  liquid anavar use of lopinavir / ritonavir and other drugs that inhibit the isoenzyme of CYP3A, may increase plasma concentrations of lopinavir. Clinical guidelines refer to “Interactions with other drugs.”

Indications
Treatment of HIV infection in adults and children from 3 years as part of combination therapy.

Contraindications

 

  • Hypersensitivity to lopinavir, ritonavir or auxiliary ingredients.
  • Severe hepatic insufficiency.
  • Concomitant use of drugs, clearance is significantly dependent on metabolism by isoenzyme CYP3A. These medications include: astemizole, blonanserin, terfenadine, midazolam, triazolam, cisapride, pimozide, rifampicin, salmeterol, sildenafil (only in the case of the treatment of pulmonary hypertension, see “Interaction with other medicinal products.”), Vardenafil, voriconazole, ergot alkaloids ( eg, ergotamine and dihydroergotamine, ergometrine and metilergometrin) reductase inhibitors Z-hydroxy-Z-CoA metilglutaril- (lovastatin, simvastatin), St. John’s wort preparations, fosamprenavir.
  • Children under 3 years of age (for children aged from 6 months to 3 years old is prescribed drug in dosage form “for oral solution”).
  • Use of the drug Kaletra ® once daily in combination with carbamazepine, phenobarbital or phenytoin.Carefully
  • Viral hepatitis B and C.
  • Cirrhosis of the liver.
  • Mild to moderate hepatic insufficiency.
  • The increased activity of “liver” enzymes.
  • Pancreatitis.
  • Hemophilia A and B.
  • Dyslipidemia (giperholesterinemnya, hypertriglyceridemia).
  • Older age (over 65 years).
  • Patients with organic heart disease, and pre-existing disorders of the cardiac conduction system or patients taking medications, lengthening the interval PR (such as verapamil or atazanavir).
  • The simultaneous use of drugs for the treatment of erectile dysfunction, namely with sildenafil (see. “Contraindications”), tadalafil.
  • Concomitant use of fentanyl, rosuvastatin, atorvastatin, bupropion, or inhaled glucocorticosteroids administered through the nose.(See. “Interaction with other medicinal products”).Pregnancy and lactation
    During pregnancy, the drug should be taken only if the potential benefit to the mother outweighs the potential risk to the fetus. Women should stop breast-feeding during the use of lopinavir / rntonavira.

    Dosing and Administration
    Inside, regardless of meals. Tablets Kaletra ® should be swallowed whole without chewing, without breaking or crushing. Adult patients The recommended oral dose of Kaletra ® is:

  • On four tablets Kaletra ® 100/25 mg (400/100 mg) twice daily without regard to meals.
  • On eight tablets of Kaletra ® 100/25 mg (800/200 mg) once daily without regard to meals for patients who showed less than 3 mutations associated with the development of resistance to lopinavir.Insufficient data for use of lopinavir / rntonavira once daily in adult patients with 3 or more mutations associated with the development of resistance to lopinavir. Concomitant therapy The use of Kaletra tablets ® in combination with omeprazole and ranntndinom does not require dose adjustment. In patients with suspected reduced sensitivity to lopinavir (shown clinically or laboratory), previously treated with antiretroviral therapy, in combination with efavirenz, nevirapine, amprenavir or nelfinavir need to increase the dose tablets Kaletra ® to 500/125 mg (5 100/25 mg tablets) twice a day 2 . While the use of these drugs pill Kaletra ® should not be administered 1 time per day. Children mode receiving Kaletra tablets ® once daily pediatric patients has not been studied. The adult dosage tablets Kaletra ® (400/100 mg twice daily) without the simultaneous application of efavirenz, nevirapine, amprenavir or nelfinavir can be used for children weighing more than 35 kg or body surface area (BSA) of 1.4 m 2 or more . To determine the dose for children weighing less than 35 kg or with a BSA between 0.6 and 1.4 m 2 is recommended to use the following table. For children with a BSA less than 0.6m or for children under 3 years of age there is a solution of the drug Kaletra ® for oral administration.

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anavar for women

Is used externally as an anavar for women antiseptic and anti-inflammatory agent for cuts, bruises, eczema, stomatitis, tonsillitis, pharyngitis, and other similar diseases. calendula tincture is also used in gynecological practice in the treatment of cervical erosion. The infusion is taken orally as a choleretic agent.

Dosage and administration:

used for minor cuts, burns, superficial wounds, for gargling in case of inflammatory diseases of the anavar for women upper respiratory tract, angina and other diseases. When applied topically and is used for gargling 1:40 aqueous solution (1 teaspoon per cup of water).

As a cholagogue taken orally 10-20 drops before meals.

Side effects:   rarely allergic anavar for women reactions.

Product form:

in glass vials.

 

Storage conditions:

in a cool, protected from anavar for women light, out of reach of children.

Shelf life:

use no later than the date specified on the package.

Conditions of supply of pharmacies:

available without a prescription.

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Cause interferon production in almost all populations of cells involved in the body’s antiviral response: T and B lymphocytes, what is anavar macrophages, granulocytes, fibroblasts, endothelial cells. When administered in a single dose  serum interferon titer reaches a maximum after 48 hours. Interferon response of the organism to the introduction Kagocel characterized by prolonged (up to 4-5 days) circulating interferon in the blood stream. Dynamics of accumulation of interferon in the gut when administered  does not coincide with the dynamics of circulating interferon titers. The serum interferon products reaches high values ??only after 48 hours after administration , while in the intestine the maximum production of interferon is observed after 4 h.

When administered at therapeutic doses, non-toxic, does not accumulate in the body. The drug is not mutagenic and teratogenic properties, is not carcinogenic, and does not have embryotoxic action.

Most effective in the treatment  achieved in his appointment no later than the 4th day from the beginning of an acute infection. The prophylactic drug can be used any time, including immediately after contact with an infectious agent.

Pharmacokinetics
24 hours after administration to what is anavar accumulates mainly in the liver, to a lesser extent in the lung, thymus, spleen, kidney, lymph nodes. Low concentration observed in the adipose tissue, heart, muscle, testis, brain, blood plasma. Low in Kagocel in the brain due to the high molecular weight of the drug makes it difficult to penetrate the blood-brain barrier. The blood plasma drug is predominantly in bound form.

With daily repeated administration what is anavar volume of distribution varies widely in all organs examined. Especially pronounced accumulation of the drug in the spleen and lymph nodes. When administered into the bloodstream misses about 20% of the what is anavar administered dose. Sucked drug circulating in the blood, mainly in the form associated with macromolecules: lipids – 47% protein – 37%). Unrelated of the drug is about 16%.

Excretion: preparation derived from organism mainly through the intestine: 7 days after introduction of the body is derived from 88% of the administered dose, including 90% – via the intestine, and 10% – kidneys. The exhaled air drug detected.

Contraindications
Individual hypersensitivity, pregnancy, childhood and adolescence.

DOSAGE AND ADMINISTRATION
For the treatment of influenza and acute what is anavar respiratory viral infections in adults appoint the first two days – 2 tablets 3 times a day for the next two days – one tablet three times a day. Total for the course – 18 tablets, course duration – 4 days.

Respiratorno- prophylaxis of viral infections in adults carried 7-day cycles, two of the day – 1 to 2 tablets per day, 5 days off, and then repeat the cycle. The duration of prophylactic course – from one week to several months.

For the treatment of herpes adults administered 2 tablets three times a day for 5 days. Total for the course -30 tablets, course duration -5 days.

For treatment of influenza and acute what is anavar respiratory viral infections in children aged 6 years prescribed in the first two days – 1 tablet 3 times a day for the next two days – one pill 2 times per day. Total for the course – 10 tablets, the duration of the course of the day -4.

Prevention of influenza and acute respiratory viral infections in children aged 6 years held a 7-day cycles: two days – 1 tablet 1 time per day, 5 days off, then repeat the cycle. The duration of prophylactic course – from one week to several months.

SIDE EFFECTS
possible development of allergic what is anavar reactions.

Overdose
In case of accidental overdose, it is recommended to appoint a plentiful drink, induce vomiting.

Interaction with other drugs
Kagocel well with other antivirals, immunomodulators and antibiotics (an additive effect).

SPECIAL INSTRUCTIONS
To achieve the therapeutic effect reception what is anavar should begin no later than the fourth day from the onset of the disease.

PACKAGING
Tablets 12 mg.

10 tablets in blisters of PVC film and aluminum foil with a heat seal coating.

1 circuit pack, along with instructions for use are placed in the pack.

SHELF LIFE.
2 years. The expiration date medication should not be used.

Storage conditions.
In dry, dark place at a temperature no higher than 25 ° C. Keep out of the reach of children. online anabolic steroids pharmacy

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anavar

Improves brain metabolism, increasing glucose and oxygen consumption of brain tissue. Increases resistance of neurons to hypoxia; enhancing glucose transport to the brain through the blood-brain barrier; It translates the process of disintegration anavar of glucose to energy more economical, aerobic pathway; selectively brain tissues; exchange enhances brain noradrenaline and serotonin; stimulates the ascending branch of the noradrenergic system, has an antioxidant effect. Reduces the aggregation of platelets and increased blood viscosity; increases the deforming ability of red blood cells and red blood cells block the recycling of adenosine; enhances oxygen release by red blood cells. It enhances the neuroprotective action of adenosine. Increases cerebral blood flow; reduces the resistance of cerebral vessels without significant changes in the systemic circulation parameters (blood pressure, minute volume, heart rate, total peripheral resistance). Not only does not have “steal” effect, and increases blood flow, especially in ischemic brain regions with low perfusion rapidly absorbed, at 1 h after oral administration to reach the maximum blood concentration. Absorption takes place mainly in the proximal gastrointestinal tract. When anavar passing through the intestinal wall is not metabolized.

 

CONTRAINDICATIONS
Acute phase of a hemorrhagic stroke, a severe form of coronary heart disease, severe arrhythmia and known hypersensitivity to vinpocetine and lactose intolerance. Pregnancy and lactation: Pregnancy, because vinpocetine crosses the placental barrier. Thus its concentration in the placenta and fetal blood is lower than in the blood of pregnant. At high doses may placental bleeding and spontaneous abortion, probably due to increased placental blood supply. Lactation: for an hour in the breast milk gets 0.25% of the dose of the drug. In anavar applying the drug must stop breastfeeding. Children younger than 18 years (due to lack of data)

DOSAGE AND ADMINISTRATION
The course of treatment and dosage is determined by the attending physician.
Inside, after a meal.
Usually a daily dosage of 15-30 mg (5-10 mg 3 times a day).
The initial daily dose is 15 mg. The maximum daily dose of 30 mg. The therapeutic effect is about a week from the beginning of treatment. The course of treatment 1 to 3 months.
With kidney and liver drug administered in the usual dose, absence of cumulation allows for long-term treatments.

SIDE EFFECTS
Side effects during treatment with the drug is rarely detected. Since the cardiovascular system: ECG changes (depression ST, prolongation of QT interval); tachycardia, arrythmia, however, a causal relationship has not been proved since in natural populations of these symptoms occur with the same frequency; labile blood pressure, feeling the tides. On the part of the central nervous system: sleep disorders (insomnia, excessive sleepiness), dizziness, headache, fatigue (these symptoms may be manifestations of the underlying disease), increased anavar sweating. On the part of the digestive system: dry mouth, nausea, heartburn. Allergic skin reactions.

 

Overdose
At present, data on overdose vinpocetine limited.
Treatment of overdose: gastric lavage, activated charcoal, symptomatic therapy.

Vzamodeystviya DRUG
interaction was observed while the use of beta-blockers (hloranolol, pindolol) Klopamid, glibenclamide, digoxin, acenocoumarol and hydrochlorothiazide, imipramine
Concomitant use Cavinton ® and methyldopa sometimes caused some increase in the hypotensive effect, so if such treatment is required regular blood pressure control.
Despite the lack of evidence supporting the possibility of interaction, it is recommended to be cautious while appointing a central drugs, antiarrhythmic and anticoagulation action.

SPECIAL INSTRUCTIONS
The presence of prolonged QT interval syndrome and receiving drugs that cause lengthening of the QT interval, requires periodic ECG monitoring.
Tablets Cavintonum ® contains lactose. In case anavar of intolerance to lactose should note that one tablet contains 41.50 mg of lactose monohydrate.

The action of the drug on the ability to drive: data on the effect of Vinpocetine on the ability to drive a car and working mechanisms, not.

Form release
tablets 10 mg.
15 tablets in a blister of PVC and aluminum foil. 2 or 6 blisters in a cardboard box with instructions for use

Shelf life
5 years.
Do not use beyond the expiration date printed on the package.

Storage conditions
List B.
At a temperature of 15-30 ° C, in a dark place, out of reach of children.

Conditions of supply of pharmacies
by prescription. steroiden kaufen

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